diff --git a/python/python-psi-impl/src/com/jetbrains/python/inspections/quickfix/PyRemoveAssignmentStatementTargetQuickFix.java b/python/python-psi-impl/src/com/jetbrains/python/inspections/quickfix/PyRemoveAssignmentStatementTargetQuickFix.java
new file mode 100644
index 000000000000..24d7b6496777
--- /dev/null
+++ b/python/python-psi-impl/src/com/jetbrains/python/inspections/quickfix/PyRemoveAssignmentStatementTargetQuickFix.java
@@ -0,0 +1,47 @@
+/*
+ * Copyright 2000-2014 JetBrains s.r.o.
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ * http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+package com.jetbrains.python.inspections.quickfix;
+
+import com.intellij.codeInsight.intention.HighPriorityAction;
+import com.intellij.codeInspection.LocalQuickFix;
+import com.intellij.codeInspection.ProblemDescriptor;
+import com.intellij.openapi.project.Project;
+import com.intellij.psi.PsiElement;
+import com.intellij.psi.util.PsiTreeUtil;
+import com.jetbrains.python.PyPsiBundle;
+import com.jetbrains.python.psi.*;
+import org.jetbrains.annotations.NotNull;
+
+public class PyRemoveAssignmentStatementTargetQuickFix implements LocalQuickFix, HighPriorityAction {
+  @NotNull
+  @Override
+  public String getFamilyName() {
+    return PyPsiBundle.message("QFIX.NAME.remove.target.expr");
+  }
+
+  @Override
+  public void applyFix(@NotNull Project project, @NotNull ProblemDescriptor descriptor) {
+    final PsiElement element = descriptor.getPsiElement();
+    final PyAssignmentStatement assignmentStatement = PsiTreeUtil.getParentOfType(element, PyAssignmentStatement.class);
+    if (assignmentStatement == null) return;
+    final PyExpression expression = assignmentStatement.getAssignedValue();
+    if (expression == null) return;
+    final PyElementGenerator elementGenerator = PyElementGenerator.getInstance(project);
+    PyExpressionStatement statement = elementGenerator.createFromText(LanguageLevel.forElement(expression), PyExpressionStatement.class,
+                                                                      expression.getText());
+    assignmentStatement.replace(statement);
+  }
+}
diff --git a/python/python-psi-impl/src/com/jetbrains/python/inspections/unusedLocal/PyUnusedLocalInspectionVisitor.java b/python/python-psi-impl/src/com/jetbrains/python/inspections/unusedLocal/PyUnusedLocalInspectionVisitor.java
index d0865f17988e..e3c517b000b7 100644
--- a/python/python-psi-impl/src/com/jetbrains/python/inspections/unusedLocal/PyUnusedLocalInspectionVisitor.java
+++ b/python/python-psi-impl/src/com/jetbrains/python/inspections/unusedLocal/PyUnusedLocalInspectionVisitor.java
@@ -4,6 +4,7 @@ package com.jetbrains.python.inspections.unusedLocal;
 import com.google.common.collect.ImmutableMap;
 import com.intellij.codeInsight.controlflow.ControlFlowUtil;
 import com.intellij.codeInsight.controlflow.Instruction;
+import com.intellij.codeInsight.intention.HighPriorityAction;
 import com.intellij.codeInspection.*;
 import com.intellij.lang.injection.InjectedLanguageManager;
 import com.intellij.openapi.project.Project;
@@ -424,7 +425,18 @@ public class PyUnusedLocalInspectionVisitor extends PyInspectionVisitor {
             continue;
           }
 
-          registerWarning(element, warningMsg, new PyRemoveStatementQuickFix());
+          final PyAssignmentStatement assignmentStatement = PsiTreeUtil.getParentOfType(element, PyAssignmentStatement.class);
+          if (assignmentStatement != null && PsiTreeUtil.isAncestor(assignmentStatement.getLeftHandSideExpression(), element, false)) {
+            if (assignmentStatement.getRawTargets().length > 1) {
+              // TODO: consider assignmentStatement.getRawTargets().length > 1 in PY-28782
+              continue;
+            }
+            if (assignmentStatement.getLeftHandSideExpression() != element) {
+              registerWarning(element, warningMsg, new ReplaceWithWildCard());
+              continue;
+            }
+            registerWarning(element, warningMsg, new PyRemoveAssignmentStatementTargetQuickFix(), new PyRemoveStatementQuickFix());
+          }
         }
       }
     }
diff --git a/python/testData/quickFixes/PyRemoveUnusedLocalQuickFixTest/removeAssignmentStatementTarget.py b/python/testData/quickFixes/PyRemoveUnusedLocalQuickFixTest/removeAssignmentStatementTarget.py
new file mode 100644
index 000000000000..3d9c7879aeee
--- /dev/null
+++ b/python/testData/quickFixes/PyRemoveUnusedLocalQuickFixTest/removeAssignmentStatementTarget.py
@@ -0,0 +1,4 @@
+class MyClass(object):
+    def __init__(self, **kwargs):
+        <caret>thing = kwargs.pop("stuff", None)
+        print("that's all folks!")
\ No newline at end of file
diff --git a/python/testData/quickFixes/PyRemoveUnusedLocalQuickFixTest/removeAssignmentStatementTarget_after.py b/python/testData/quickFixes/PyRemoveUnusedLocalQuickFixTest/removeAssignmentStatementTarget_after.py
new file mode 100644
index 000000000000..794b6c4b3d90
--- /dev/null
+++ b/python/testData/quickFixes/PyRemoveUnusedLocalQuickFixTest/removeAssignmentStatementTarget_after.py
@@ -0,0 +1,4 @@
+class MyClass(object):
+    def __init__(self, **kwargs):
+        kwargs.pop("stuff", None)
+        print("that's all folks!")
\ No newline at end of file
diff --git a/python/testSrc/com/jetbrains/python/quickFixes/PyRemoveUnusedLocalQuickFixTest.java b/python/testSrc/com/jetbrains/python/quickFixes/PyRemoveUnusedLocalQuickFixTest.java
index 769f9aaaff9c..ed187db02826 100644
--- a/python/testSrc/com/jetbrains/python/quickFixes/PyRemoveUnusedLocalQuickFixTest.java
+++ b/python/testSrc/com/jetbrains/python/quickFixes/PyRemoveUnusedLocalQuickFixTest.java
@@ -59,6 +59,13 @@ public class PyRemoveUnusedLocalQuickFixTest extends PyQuickFixTestCase {
     });
   }
 
+  // PY-17901
+  public void testRemoveAssignmentStatementTarget() {
+    runWithLanguageLevel(LanguageLevel.getLatest(), () -> {
+      doQuickFixTest(PyUnusedLocalInspection.class, PyPsiBundle.message("QFIX.NAME.remove.target.expr"));
+    });
+  }
+
   // PY-32037
   public void testGeneratorIterator() {
     doQuickFixTest(PyUnusedLocalInspection.class, PyPsiBundle.message("INSP.unused.locals.replace.with.wildcard"));