diff --git a/python/python-psi-impl/src/com/jetbrains/python/codeInsight/completion/PyFStringLikeCompletionContributor.java b/python/python-psi-impl/src/com/jetbrains/python/codeInsight/completion/PyFStringLikeCompletionContributor.java
index 5ec0c4c2bea5..8c731afac349 100644
--- a/python/python-psi-impl/src/com/jetbrains/python/codeInsight/completion/PyFStringLikeCompletionContributor.java
+++ b/python/python-psi-impl/src/com/jetbrains/python/codeInsight/completion/PyFStringLikeCompletionContributor.java
@@ -65,7 +65,12 @@ public class PyFStringLikeCompletionContributor extends CompletionContributor {
           return;
         }
         String completionPrefix = stringElemText.substring(braceOffset + 1, relOffset);
-        if (!PyNames.isIdentifier(completionPrefix)) {
+        boolean autoPopupAfterOpeningBrace = completionPrefix.isEmpty() && parameters.isAutoPopup();
+        if (autoPopupAfterOpeningBrace) {
+          return;
+        }
+        boolean impossibleReferencePrefix = !completionPrefix.isEmpty() && !PyNames.isIdentifier(completionPrefix);
+        if (impossibleReferencePrefix) {
           return;
         }
         PyExpression fString = PyUtil.createExpressionFromFragment("f" + stringElemText, stringLiteral.getParent());
diff --git a/python/testData/completion/fStringLikeCompletionAvailableRightAfterOpeningBrace.py b/python/testData/completion/fStringLikeCompletionAvailableRightAfterOpeningBrace.py
new file mode 100644
index 000000000000..6fadbe71ecd2
--- /dev/null
+++ b/python/testData/completion/fStringLikeCompletionAvailableRightAfterOpeningBrace.py
@@ -0,0 +1,2 @@
+my_expr = 42
+s = 'foo{<caret>'
diff --git a/python/testSrc/com/jetbrains/python/Py3CompletionTest.java b/python/testSrc/com/jetbrains/python/Py3CompletionTest.java
index 61d5adbc85e2..5fe1f896d835 100644
--- a/python/testSrc/com/jetbrains/python/Py3CompletionTest.java
+++ b/python/testSrc/com/jetbrains/python/Py3CompletionTest.java
@@ -7,6 +7,7 @@ import com.intellij.openapi.module.Module;
 import com.intellij.testFramework.LightProjectDescriptor;
 import com.intellij.testFramework.PsiTestUtil;
 import com.intellij.testFramework.TestDataPath;
+import com.intellij.util.containers.ContainerUtil;
 import com.jetbrains.python.fixtures.PyTestCase;
 import com.jetbrains.python.inspections.PyMethodParametersInspection;
 import com.jetbrains.python.psi.LanguageLevel;
@@ -477,6 +478,17 @@ public class Py3CompletionTest extends PyTestCase {
     runWithLanguageLevel(LanguageLevel.getLatest(), this::doNegativeTest);
   }
 
+  // PY-45459
+  public void testFStringLikeCompletionAvailableRightAfterOpeningBrace() {
+    runWithLanguageLevel(LanguageLevel.getLatest(), () -> {
+      myFixture.configureByFile(getTestName(true) + ".py");
+      LookupElement[] variants = myFixture.completeBasic();
+      assertNotNull(variants);
+      assertTrue(variants.length > 0);
+      assertTrue(ContainerUtil.exists(variants, v -> v.getLookupString().equals("my_expr")));
+    });
+  }
+
   @Override
   protected String getTestDataPath() {
     return super.getTestDataPath() + "/completion";