diff --git a/RegExpSupport/src/org/intellij/lang/regexp/inspection/custom/CustomRegExpInspection.java b/RegExpSupport/src/org/intellij/lang/regexp/inspection/custom/CustomRegExpInspection.java
index 76c885f5fee2..c3acfe495d7c 100644
--- a/RegExpSupport/src/org/intellij/lang/regexp/inspection/custom/CustomRegExpInspection.java
+++ b/RegExpSupport/src/org/intellij/lang/regexp/inspection/custom/CustomRegExpInspection.java
@@ -1,4 +1,4 @@
-// Copyright 2000-2025 JetBrains s.r.o. and contributors. Use of this source code is governed by the Apache 2.0 license.
+// Copyright 2000-2026 JetBrains s.r.o. and contributors. Use of this source code is governed by the Apache 2.0 license.
 package org.intellij.lang.regexp.inspection.custom;
 
 import com.intellij.codeInsight.daemon.HighlightDisplayKey;
@@ -34,6 +34,8 @@ import org.jetbrains.annotations.Nullable;
 import java.util.List;
 import java.util.function.Function;
 
+import static com.intellij.codeInspection.ProblemHighlightType.GENERIC_ERROR_OR_WARNING;
+
 /**
  * @author Bas Leijdekkers
  */
@@ -77,7 +79,7 @@ public final class CustomRegExpInspection extends LocalInspectionTool implements
     for (RegExpInspectionConfiguration configuration : myConfigurations) {
       final String uuid = configuration.getUuid();
       final ToolsImpl tools = profile.getToolsOrNull(uuid, project);
-      if (tools != null && !tools.isEnabled(file)) {
+      if (tools == null || !tools.isEnabled(file)) {
         continue;
       }
       addInspectionToProfile(project, profile, configuration); // hack
@@ -85,7 +87,7 @@ public final class CustomRegExpInspection extends LocalInspectionTool implements
 
       for (RegExpInspectionConfiguration.InspectionPattern pattern : configuration.getPatterns()) {
         FileType fileType = pattern.fileType();
-        if (UnknownFileType.INSTANCE != fileType && file.getFileType() != fileType) continue;
+        if (fileType != null && fileType != UnknownFileType.INSTANCE && file.getFileType() != fileType) continue;
         final FindModel model = new FindModel();
         model.setRegularExpressions(true);
         model.setRegExpFlags(pattern.flags);
@@ -108,9 +110,11 @@ public final class CustomRegExpInspection extends LocalInspectionTool implements
           final int start = result.getStartOffset() - elementRange.getStartOffset();
           final TextRange warningRange = new TextRange(start, result.getEndOffset() - result.getStartOffset() + start);
           final String problemDescriptor = StringUtil.defaultIfEmpty(configuration.getProblemDescriptor(), configuration.getName());
-          final CustomRegExpQuickFix fix = replacement == null ? null : new CustomRegExpQuickFix(findManager, model, text, result);
+          final LocalQuickFix[] fix = replacement == null 
+                                      ? LocalQuickFix.EMPTY_ARRAY 
+                                      : new LocalQuickFix[] {new CustomRegExpQuickFix(findManager, model, text, result)};
           final ProblemDescriptor descriptor =
-            manager.createProblemDescriptor(element, warningRange, problemDescriptor, ProblemHighlightType.GENERIC_ERROR_OR_WARNING, isOnTheFly, fix);
+            manager.createProblemDescriptor(element, warningRange, problemDescriptor, GENERIC_ERROR_OR_WARNING, isOnTheFly, fix);
           descriptors.add(new ProblemDescriptorWithReporterName((ProblemDescriptorBase)descriptor, uuid));
           result = findManager.findString(text, result.getEndOffset(), model, vFile);
         }
@@ -186,7 +190,9 @@ public final class CustomRegExpInspection extends LocalInspectionTool implements
     return myConfigurations;
   }
 
-  public @NotNull InspectionMetaDataDialog createMetaDataDialog(Project project, @NotNull String profileName, @Nullable RegExpInspectionConfiguration configuration) {
+  public @NotNull InspectionMetaDataDialog createMetaDataDialog(@NotNull Project project, 
+                                                                @NotNull String profileName, 
+                                                                @Nullable RegExpInspectionConfiguration configuration) {
     Function<String, @Nullable @NlsContexts.DialogMessage String> nameValidator = name -> {
       for (RegExpInspectionConfiguration current : myConfigurations) {
         if ((configuration == null || !configuration.getUuid().equals(current.getUuid())) &&
diff --git a/RegExpSupport/test/org/intellij/lang/regexp/inspection/custom/CustomRegExpInspectionTest.java b/RegExpSupport/test/org/intellij/lang/regexp/inspection/custom/CustomRegExpInspectionTest.java
new file mode 100644
index 000000000000..f0eb00a1470d
--- /dev/null
+++ b/RegExpSupport/test/org/intellij/lang/regexp/inspection/custom/CustomRegExpInspectionTest.java
@@ -0,0 +1,43 @@
+// Copyright 2000-2026 JetBrains s.r.o. and contributors. Use of this source code is governed by the Apache 2.0 license.
+package org.intellij.lang.regexp.inspection.custom;
+
+import com.intellij.codeInspection.ex.InspectionProfileImpl;
+import com.intellij.find.FindModel.SearchContext;
+import com.intellij.openapi.project.Project;
+import com.intellij.profile.codeInspection.InspectionProfileManager;
+import com.intellij.testFramework.fixtures.BasePlatformTestCase;
+
+/**
+ * @author Bas Leijdekkers
+ */
+public class CustomRegExpInspectionTest extends BasePlatformTestCase {
+
+  public void testMultipleCustomInspections() {
+    myFixture.enableInspections(new CustomRegExpInspection());
+    Project project = myFixture.getProject();
+    InspectionProfileImpl profile = InspectionProfileManager.getInstance(project).getCurrentProfile();
+    CustomRegExpInspection inspection = CustomRegExpInspection.getCustomRegExpInspection(profile);
+    RegExpInspectionConfiguration one = new RegExpInspectionConfiguration("one");
+    one.addPattern(new RegExpInspectionConfiguration.InspectionPattern("one", null, 0, SearchContext.ANY, null));
+    inspection.addConfiguration(one);
+    CustomRegExpInspection.addInspectionToProfile(project, profile, one);
+    RegExpInspectionConfiguration two = new RegExpInspectionConfiguration("two");
+    two.addPattern(new RegExpInspectionConfiguration.InspectionPattern("two", null, 0, SearchContext.ANY, null));
+    inspection.addConfiguration(two);
+    // configuration "two" is not yet added to the inspection profile
+    myFixture.configureByText("dummy.txt", """
+      <warning descr="one">one</warning>
+      two
+      three
+      """);
+    myFixture.testHighlighting(true, true, true);
+
+    CustomRegExpInspection.addInspectionToProfile(project, profile, two);
+    myFixture.configureByText("dummy.txt", """
+      <warning descr="one">one</warning>
+      <warning descr="two">two</warning>
+      three
+      """);
+    myFixture.testHighlighting(true, true, true);
+  }
+}
\ No newline at end of file