diff --git a/python/src/META-INF/python-core-common.xml b/python/src/META-INF/python-core-common.xml
index 05c699c4e901..990b7ec7a818 100644
--- a/python/src/META-INF/python-core-common.xml
+++ b/python/src/META-INF/python-core-common.xml
@@ -711,6 +711,10 @@
 
     <!-- PyQt -->
     <typeProvider implementation="com.jetbrains.pyqt.PyQtTypeProvider"/>
+    
+    <!-- PyFunctionTypeAnnotation -->
+    <visitorFilter language="PyFunctionTypeComment"
+                   implementationClass="com.jetbrains.python.codeInsight.functionTypeComments.PyFunctionTypeAnnotationVisitorFilter"/>
   </extensions>
 
   <actions>
diff --git a/python/src/com/jetbrains/python/codeInsight/functionTypeComments/PyFunctionTypeAnnotationVisitorFilter.java b/python/src/com/jetbrains/python/codeInsight/functionTypeComments/PyFunctionTypeAnnotationVisitorFilter.java
new file mode 100644
index 000000000000..9a80da979cb3
--- /dev/null
+++ b/python/src/com/jetbrains/python/codeInsight/functionTypeComments/PyFunctionTypeAnnotationVisitorFilter.java
@@ -0,0 +1,37 @@
+/*
+ * Copyright 2000-2016 JetBrains s.r.o.
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ * http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+package com.jetbrains.python.codeInsight.functionTypeComments;
+
+import com.intellij.psi.PsiFile;
+import com.jetbrains.python.inspections.*;
+import org.jetbrains.annotations.NotNull;
+
+/**
+ * @author Mikhail Golubev
+ */
+public class PyFunctionTypeAnnotationVisitorFilter implements PythonVisitorFilter {
+  @Override
+  public boolean isSupported(@NotNull Class visitorClass, @NotNull PsiFile file) {
+    return !(visitorClass == PyIncorrectDocstringInspection.class ||
+             visitorClass == PyMissingOrEmptyDocstringInspection.class ||
+             visitorClass == PySingleQuotedDocstringInspection.class ||
+             visitorClass == PyByteLiteralInspection.class ||
+             visitorClass == PyMandatoryEncodingInspection.class ||
+             visitorClass == PyNonAsciiCharInspection.class ||
+             visitorClass == PyInterpreterInspection.class ||
+             visitorClass == PyPep8Inspection.class);
+  }
+}
diff --git a/python/testData/inspections/InspectionsDisabledInFunctionTypeComments/test.py b/python/testData/inspections/InspectionsDisabledInFunctionTypeComments/test.py
new file mode 100644
index 000000000000..96e5ed040197
--- /dev/null
+++ b/python/testData/inspections/InspectionsDisabledInFunctionTypeComments/test.py
@@ -0,0 +1,8 @@
+<weak_warning descr="Missing docstring"></weak_warning><warning descr="No encoding specified for file"></warning>def <weak_warning descr="Missing docstring">f</weak_warning>(x):
+    <warning descr="Byte literal contains characters > 255"><warning descr="Non-ASCII character М in file, but no encoding declared"># type: (b'Моноцикл') -> None</warning></warning>
+    pass
+
+
+def <weak_warning descr="Missing docstring">g</weak_warning>():
+    # type: <error descr="unexpected tokens">"foo"</error>
+    pass
diff --git a/python/testSrc/com/jetbrains/python/PythonInspectionsTest.java b/python/testSrc/com/jetbrains/python/PythonInspectionsTest.java
index c6a3ee5e4bf5..5fd58dbc787c 100644
--- a/python/testSrc/com/jetbrains/python/PythonInspectionsTest.java
+++ b/python/testSrc/com/jetbrains/python/PythonInspectionsTest.java
@@ -351,4 +351,17 @@ public class PythonInspectionsTest extends PyTestCase {
   public void testPyDunderSlotsInspection() {
     runWithLanguageLevel(LanguageLevel.PYTHON30, () -> doHighlightingTest(PyDunderSlotsInspection.class));
   }
+
+  // PY-21645
+  public void testInspectionsDisabledInFunctionTypeComments() {
+    myFixture.enableInspections(PyIncorrectDocstringInspection.class); 
+    myFixture.enableInspections(PyMissingOrEmptyDocstringInspection.class);
+    myFixture.enableInspections(PySingleQuotedDocstringInspection.class); 
+    myFixture.enableInspections(PyByteLiteralInspection.class); 
+    myFixture.enableInspections(PyMandatoryEncodingInspection.class); 
+    myFixture.enableInspections(PyNonAsciiCharInspection.class); 
+
+    myFixture.configureByFile("inspections/" + getTestName(false) + "/test.py");
+    myFixture.checkHighlighting(true, false, true);
+  }
 }