diff --git a/python/helpers/pydev/pydev_ipython/inputhook.py b/python/helpers/pydev/pydev_ipython/inputhook.py
index 37370ef88452..97f3a4a24582 100644
--- a/python/helpers/pydev/pydev_ipython/inputhook.py
+++ b/python/helpers/pydev/pydev_ipython/inputhook.py
@@ -27,6 +27,7 @@ GUI_QT = 'qt'
 GUI_QT4 = 'qt4'
 GUI_QT5 = 'qt5'
 GUI_QT6 = 'qt6'
+GUI_PYSIDE = 'pyside'
 GUI_GTK = 'gtk'
 GUI_TK = 'tk'
 GUI_OSX = 'osx'
@@ -180,9 +181,11 @@ class InputHookManager(object):
         self.clear_inputhook()
 
     def enable_qt(self, app=None):
-        from pydev_ipython.qt_for_kernel import QT_API, QT_API_PYQT5, QT_API_PYQT6
+        from pydev_ipython.qt_for_kernel import QT_API, QT_API_PYQT5, QT_API_PYQT6, QT_API_PYSIDE
         if QT_API == QT_API_PYQT6:
             self.enable_qt6(app)
+        elif QT_API == QT_API_PYSIDE:
+            self.enable_pyside(app)
         elif QT_API == QT_API_PYQT5:
             self.enable_qt5(app)
         else:
@@ -245,7 +248,7 @@ class InputHookManager(object):
 
     def enable_qt6(self, app=None):
         from pydev_ipython.inputhookqt6 import create_inputhook_qt6
-        app, inputhook_qt6 = create_inputhook_qt6(self, app)
+        app, inputhook_qt6 = create_inputhook_qt6(self, app, GUI_QT6)
         self.set_inputhook(inputhook_qt6)
 
         self._current_gui = GUI_QT6
@@ -253,6 +256,16 @@ class InputHookManager(object):
         self._apps[GUI_QT6] = app
         return app
 
+    def enable_pyside(self, app=None):
+        from pydev_ipython.inputhookqt6 import create_inputhook_qt6
+        app, inputhook_pyside = create_inputhook_qt6(self, app, GUI_PYSIDE)
+        self.set_inputhook(inputhook_pyside)
+
+        self._current_gui = GUI_PYSIDE
+        app._in_event_loop = True
+        self._apps[GUI_PYSIDE] = app
+        return app
+
     def disable_qt6(self):
         if GUI_QT6 in self._apps:
             self._apps[GUI_QT6]._in_event_loop = False
diff --git a/python/helpers/pydev/pydev_ipython/inputhookqt6.py b/python/helpers/pydev/pydev_ipython/inputhookqt6.py
index c3fb95940d3a..f92092a4d47d 100644
--- a/python/helpers/pydev/pydev_ipython/inputhookqt6.py
+++ b/python/helpers/pydev/pydev_ipython/inputhookqt6.py
@@ -22,8 +22,7 @@ import signal
 import threading
 
 
-from PyQt6 import QtCore, QtGui
-from pydev_ipython.inputhook import allow_CTRL_C, ignore_CTRL_C, stdin_ready
+from pydev_ipython.inputhook import allow_CTRL_C, ignore_CTRL_C, stdin_ready, GUI_QT6, GUI_PYSIDE
 
 # To minimise future merging complexity, rather than edit the entire code base below
 # we fake InteractiveShell here
@@ -51,7 +50,7 @@ sigint_timer = None
 # Code
 #-----------------------------------------------------------------------------
 
-def create_inputhook_qt6(mgr, app=None):
+def create_inputhook_qt6(mgr, app=None, gui=GUI_QT6):
     """Create an input hook for running the Qt6 application event loop.
 
     Parameters
@@ -79,10 +78,18 @@ def create_inputhook_qt6(mgr, app=None):
     """
 
     if app is None:
-        app = QtCore.QCoreApplication.instance()
-        if app is None:
-            from PyQt6 import QtWidgets
-            app = QtWidgets.QApplication([" "])
+        if gui == GUI_QT6:
+            from PyQt6 import QtCore
+            app = QtCore.QCoreApplication.instance()
+            if app is None:
+                from PyQt6 import QtWidgets
+                app = QtWidgets.QApplication([" "])
+        elif gui == GUI_PYSIDE:
+            from PySide6 import QtCore
+            app = QtCore.QCoreApplication.instance()
+            if app is None:
+                from PySide6 import QtWidgets
+                app = QtWidgets.QApplication([" "])
 
     # Re-use previously created inputhook if any
     ip = InteractiveShell.instance()
diff --git a/python/helpers/pydev/pydev_ipython/qt_loaders.py b/python/helpers/pydev/pydev_ipython/qt_loaders.py
index eef183ca1c2b..86f3447f04ea 100644
--- a/python/helpers/pydev/pydev_ipython/qt_loaders.py
+++ b/python/helpers/pydev/pydev_ipython/qt_loaders.py
@@ -23,10 +23,13 @@ QT_API_PYQT5 = 'pyqt5'
 QT_API_PYQT6 = 'pyqt6'
 
 
-def find_module(module_name, path=None):
+def find_module(module_name, path=None, parent_name=None):
     spec = importlib.util.find_spec(module_name, path)
     if spec is None:
-        raise ImportError
+        if parent_name is not None:
+            spec = importlib.util.find_spec(parent_name + '.' + module_name, path)
+        if spec is None:
+            raise ImportError
 
 
 class ImportDenier(object):
@@ -66,7 +69,7 @@ def commit_api(api):
         ID.forbid('PyQt5')
         ID.forbid('PyQt6')
     else:
-        ID.forbid('PySide')
+        ID.forbid('PySide6')
 
 
 def loaded_api():
@@ -84,7 +87,7 @@ def loaded_api():
             return QT_API_PYQT
         else:
             return QT_API_PYQTv1
-    elif 'PySide.QtCore' in sys.modules:
+    elif 'PySide6.QtCore' in sys.modules:
         return QT_API_PYSIDE
     elif 'PyQt5.QtCore' in sys.modules:
         return QT_API_PYQT5
@@ -94,7 +97,7 @@ def loaded_api():
 
 
 def has_binding(api):
-    """Safely check for PyQt4 or PySide, without importing
+    """Safely check for PyQt4 or PySide6, without importing
        submodules
 
        Parameters
@@ -109,7 +112,7 @@ def has_binding(api):
     # we can't import an incomplete pyside and pyqt4
     # this will cause a crash in sip (#1431)
     # check for complete presence before importing
-    module_name = {QT_API_PYSIDE: 'PySide',
+    module_name = {QT_API_PYSIDE: 'PySide6',
                    QT_API_PYQT: 'PyQt4',
                    QT_API_PYQTv1: 'PyQt4',
                    QT_API_PYQT_DEFAULT: 'PyQt4',
@@ -119,16 +122,16 @@ def has_binding(api):
     module_name = module_name[api]
 
     try:
-        #importing top level PyQt4/PySide module is ok...
+        #importing top level PyQt4/PySide6 module is ok...
         mod = __import__(module_name)
         #...importing submodules is not
-        find_module('QtCore', mod.__path__)
-        find_module('QtGui', mod.__path__)
-        find_module('QtSvg', mod.__path__)
+        find_module('QtCore', mod.__path__, mod.__name__)
+        find_module('QtGui', mod.__path__, mod.__name__)
+        find_module('QtSvg', mod.__path__, mod.__name__)
 
-        #we can also safely check PySide version
+        #we can also safely check PySide6 version
         if api == QT_API_PYSIDE:
-            return check_version(mod.__version__, '1.0.3')
+            return check_version(mod.__version__, '6.0.0')
         else:
             return True
     except ImportError:
@@ -191,7 +194,7 @@ def import_pyqt4(version=2):
         raise ImportError("IPython requires PyQt4 >= 4.7, found %s" %
                           QtCore.PYQT_VERSION_STR)
 
-    # Alias PyQt-specific functions for PySide compatibility.
+    # Alias PyQt-specific functions for PySide6 compatibility.
     QtCore.Signal = QtCore.pyqtSignal
     QtCore.Slot = QtCore.pyqtSlot
 
@@ -208,7 +211,7 @@ def import_pyqt5():
     """
     from PyQt5 import QtGui, QtCore, QtSvg
 
-    # Alias PyQt-specific functions for PySide compatibility.
+    # Alias PyQt-specific functions for PySide6 compatibility.
     QtCore.Signal = QtCore.pyqtSignal
     QtCore.Slot = QtCore.pyqtSlot
 
@@ -217,7 +220,7 @@ def import_pyqt5():
 def import_pyqt6():
     from PyQt6 import QtGui, QtCore, QtSvg
 
-    # Alias PyQt-specific functions for PySide compatibility.
+    # Alias PyQt-specific functions for PySide6 compatibility.
     QtCore.Signal = QtCore.pyqtSignal
     QtCore.Slot = QtCore.pyqtSlot
 
@@ -226,11 +229,11 @@ def import_pyqt6():
 
 def import_pyside():
     """
-    Import PySide
+    Import PySide6
 
     ImportErrors raised within this function are non-recoverable
     """
-    from PySide import QtGui, QtCore, QtSvg  # @UnresolvedImport
+    from PySide6 import QtGui, QtCore, QtSvg  # @UnresolvedImport
     return QtCore, QtGui, QtSvg, QT_API_PYSIDE
 
 
@@ -287,14 +290,14 @@ def load_qt(api_options):
     else:
         raise ImportError("""
     Could not load requested Qt binding. Please ensure that
-    PyQt4 >= 4.7 or PySide >= 1.0.3 is available,
+    PyQt4 >= 4.7 or PySide6 >= 6.0.0 is available,
     and only one is imported per session.
 
     Currently-imported Qt library:   %r
     PyQt4 installed:                 %s
     PyQt5 installed:                 %s
     PyQt6 installed:                 %s
-    PySide >= 1.0.3 installed:       %s
+    PySide6 >= 6.0.0 installed:      %s
     Tried to load:                   %r
     """ % (loaded_api(),
            has_binding(QT_API_PYQT),